Molecular profiling of malignant pleural mesothelioma and pulmonary fibrosis
نویسنده
چکیده
.........................................................................................................................5 I REVIEW OF THE LITERATURE...................................................................................8 1 ASBESTOS FIBRES .........................................................................................................8 1.1.1 Oxidative stress and antioxidant pathways ...............................................................11 1.1.2 Nuclear factor-kappa B (NFB) and tumor necrosis factor(TNF)....................13 1.1.3 Epidermal growth factor receptor (EGFR) mediated pathway...................................14 1.1.4 Transforming growth factor(TGF) ....................................................................14 2 MALIGNANT MESOTHELIOMA (MM).....................................................................15 2.2.1 DNA copy number changes in MM..........................................................................19 3 IDIOPATHIC PULMONARY FIBROSIS (IPF) ...........................................................28 3.1.1 Transforming growth factor– (TGF)....................................................................31 3.1.2 Bone morphogenetic proteins (BMPs) and gremlin ..................................................32 4 HIGH-RESOLUTION PROFILING METHODS IN FINDING MARKERS FOR DETECTION OF DISEASES............................................................................................35 1.1 Genes and pathways affected by asbestos fibres............................................................9 1.2 Asbestos-related diseases ..............................................................................................15 2.1 Histological classification of MM .................................................................................17 2.2 Molecular genetics and pathology of MM ...................................................................18 2.3 Diagnoses and prognosis of MM patients ....................................................................23 2.4 MM therapy options, and treatment resistance...........................................................25 3.2 Diagnosis and prognosis of lung fibrosis......................................................................34 4.1 Microarray platforms...................................................................................................35 4.2 Asbestos associated signatures .....................................................................................36
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